The Buck Institute has an opening for a Postdoctoral Researcher to study protein folding problems during stress and cellular aging in the lab of Dr. Kai Zhou. The Zhou lab uses budding yeast as the main model organism to research the principles of protein folding and how this process is affected by environmental stress and the aging process, as well as how the protein folding problems feedback to cellular aging. Budding yeast is an ideal model to study how mother cells age and how daughter cells reset their aging clock; both fates happen at the same time along the axis of asymmetric cell division.
We use multiple cutting-edge imaging methods, high-throughput screening, biochemistry, bioinformatics, and machine learning to systematically address the response of cellular proteome towards stress and aging. We also design and engineer new tools to solve the problems we face. As protein folding problems are featured and conserved in aging and many age-related diseases, including neuro-degenerative diseases, our strategy is to take advantage of the high-throughput platforms in budding yeast and use the novel mechanisms revealed by yeast projects to guide further exploration in other animal models (e.g. fruit fly) for aging and age-related diseases. We follow basic questions and use unbiased screens to find answers and candidate proteins/genes, which are followed in detail to highlight the molecular mechanisms and gain insight into the principle of cell biology of proteostasis.
The Postdoctoral Fellow is encouraged to finish 1-2 projects and publish high profile papers within 5 years and take the projects to his/her own lab in the future.
· Ph.D. or M.D. degree in biology or related fields.
· Published research in peer-reviewed journals.
· Strong interest in proteostasis and cell biology.
· Previous research experience in cell biology or yeast biology is preferred.
ABOUT THE ZHOU LAB
We will apply genetics, cell biology, proteomics, biochemistry, imaging and bioinformatics to solve protein folding and aging–related questions. This is a new laboratory and we are a group of exciting young researchers trying to establish a new research program related to aging. Cool discoveries and enjoying science are what we value the most.