Cutting-edge tissue staining and quantitative digital image analysis are key components of many Cancer Center research projects. In order to meet increasing research needs, the MGB Cancer Center has launched a Translational Research Imaging Core focused on combining the latest advances in protein and RNA biomarker staining with quantitative digital microscopy analytics to understand cancer biology. This core is in partnership with the Biomarker Discovery Lab (https://www.massgeneral.org/cancer-center/clinical-trials-and-research/biomarker-discovery-lab) and the Immuno-Oncology Biomarker Lab.
As a critical member of the team, the candidate will assist in development of biomarker staining panels, staining and imaging of tissue specimens, and downstream computational image analysis using high-end commercial analysis software and computational languages such as R or Python. These skills can be learned on the job. The technician will be closely supervised by the core facility manager but will have the opportunity to perform self-directed work by contributing to hypothesis generation, experimental design, and data interpretation. The technician will also be responsible for making figures for manuscripts and drafting summary reports. Key contribution to projects has the potential to lead to authorship in scientific publications and presentations.
We are seeking an applicant who is highly motivated, exceptionally organized, detail-oriented, and willing to learn. The candidate will have strong analytic and problem-solving skills required to troubleshoot experimental issues. We employ a team-based interdisciplinary approach, working with researchers from diverse backgrounds. As such, the candidate must have excellent communication skills and the ability to work well with others.
This is an ideal position for individuals who are interested in working at the interface of research and clinical medicine. This full-time position has potential for growth.
About Massachusetts General Hospital – Translational Research Imaging Core
We develop and optimize scalable next-generation imaging and staining methods for both basic science and translational cancer research.
We are a part of the Massachusetts General Hospital Cancer Center and Department of Pathology and work closely with other researchers at outside institutions such as the Broad Institute. Our goal is to enhance cancer research by utilizing the latest high-plex staining and advanced imaging techniques coupled with state-of-the-art image quantification tools. We have extensive experience with standard IHC and fluorescence stains as well as complex spatial profiling of multiplex protein and RNA assays on tissue and liquid biopsy specimens. Project-specific image analysis tools are created using sophisticated commercial software and custom in-house software. We provide a range of resources, from targeted training for user-facilitated research to more involved collaborative efforts.