Ashvattha Therapeutics Inc. is a biopharmaceutical company developing products for the unmet medical needs utilizing a novel dendrimer technology exclusively licensed from Johns Hopkins University. We are currently looking for outstanding individuals to join our research and development department and contribute to our rapidly expanding portfolio of therapeutic products. We are seeking a passionate and creative, Senior Scientist with a strong background and experience in cell and molecular biology for developing in vitro based platforms and assays for evaluating the efficacy of pipeline candidates. Hands-on experience in confocal and fluorescent microscopy is highly desired for evaluating the in vitro and in vivo cellular and tissue distribution of dendrimer nanoparticles. The selected candidate will contribute technical expertise and scientific knowledge towards the development of dendrimer nanotherapeutics against a variety of targets in cancer and inflammatory diseases. The candidate will lead biological research program: propose novel therapeutic targets, develop and execute experiments, and transform insights from the laboratory into Ashvattha’s broader objectives of improving dendrimer drug therapeutics. As a Senior Scientist in the Biology team at Ashvattha, the candidate will drive the advancement of our broad dendrimer based drug discovery pipeline, leading the biology efforts for our drug discovery programs.
Duties and Responsibilities — Essential Functions
Lead biology activities for discovery projects while collaborating with chemists and engineers.
Implement strategic designs and execute independent experiments using tissue culture and animal models.
Design and execute experiments that contribute to the advancement of discovery programs by developing cell-based assays and in-vivo studies to evaluate efficacy and distribution of lead candidates
Provide scientific and technical leadership on therapeutic hypothesis, animal models and biomarker validation.
Evaluate libraries of dendrimer-drug conjugates in preclinical studies in the context of neurological disorders, eye disease, oncology and other healthcare applications.
Collaborate with research teams to identify, validate and characterize cell-based assays and animal models that directly address drug discovery and program validation
Perform various in vitro immune cell assays such as ELISA, immunophenotyping by flow cytometry/FACS, intracellular cytokine staining, proliferation assays, co-culture, and immune cell isolation.
Well-versed with advanced microscopy imaging techniques (confocal and fluorescence)
Design, monitor and support technical transfer of methods for external studies performed at Contract Research Organizations and/or with academic collaborators.
Write technical reports and present data/results to the project teams; perform literature search on new discovery programs and author new project proposals (including request for funding).
· M.S.+5-8 or Ph.D.+3 years of experience in immunology, cancer biology, or related discipline.
· Experience in inflammation, immuno-oncology, molecular biology, and cell biology is preferred.
· A strong understanding of biology, tumor immunology, and inflammatory diseases.
· Experience in in vitro analyses of polymer/dendrimer-drug conjugates, peptide/antibody conjugates, hydrogels, protein and/or other biomolecules.
· Extensive knowledge and experience performing and developing assays used in a preclinical settings.
· Core techniques: ELISA, western blotting, qPCR, fluorescence microscopy.
· Experience with FlowJo, GraphPad Prism, SoftMax, Excel, or other similar software.
· A track record of demonstrating scientific vigor and creativity while carrying out independent research
· Independently analyze scientific results, troubleshoot methods, conceive creative solutions, and extract key findings.
· Experienced in supervising others, leading scientific teams and working in a matrix environment